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KMID : 0861020090240030103
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Korea Journal of Herbology
2009 Volume.24 No. 3 p.103 ~ p.108
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Anti-oxidative Effects of Taraxaci Herba and Protective Effects on Human HaCaT Keratinocyte )
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Kim Hyung-Woo
Kim Byung-Joo
Lim Se-Hyun
Kim Hyun-Yung
Lee Sook-Young
Cho Su-In
Kim Young-Kyoon
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Abstract
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Objectives : This study was carried out to investigate anti-oxidative effects of Taraxaci Herba (TH) and protective effects on Human HaCaT keratinocyte.
Methods : Anti-oxidative effects were measured by estimating the amount of total phenolics and flavonoids. In addition, DPPH free radical scavenging activities were estimated. Protective effects of TH on HaCaT keratinocytes against oxidative stress induced by hydrogen peroxide were also measured.
Results : In our results, treatment with TH did not show cytotoxicity on HaCaT keratinocyte beneath the concentration of 200 g/ml. 42.641.90 g/ml of total phenolics and 28.091.84 g/ml of flavonoids was detected from TH ethanol extract. In addition, DPPH free radical scavenging activities of TH were elevated in dose-dependent manner. In addition, The value of half maximal inhibitory concentration (IC) was 165.5 g/ml. Finally, TH showed protective effect against cell death of HaCaT cell induced by hydrogen peroxide significantly.
Conclusions : In conclusion, these results suggest that TH may have anti-oxidantic action in human skin and also suggest the possibility as cosmetic material.
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KEYWORD
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Taraxaci Herba, anti-oxidative effect, HaCaT keratinocyte
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